Gastric Cancer, An Issue of Gastroenterology Clinics, 1e (The Clinics: Internal Medicine)

Gastric Cancer: A Comprehensive Overview

Despite a decline in its incidence over the past century in the United States, gastric cancer remains a formidable foe in the global battle against cancer, ranking as the second-most common cause of cancer-related deaths worldwide. Its prevalence is particularly pronounced among immigrant populations and those facing socioeconomic hardships.

In recent years, our understanding of gastric cancer’s pathogenesis has undergone a remarkable transformation. The pivotal role of Helicobacter pylori, a contentious bacteria dwelling within the stomach, has become increasingly apparent, along with its capacity to incite an inflammatory response. This inflammatory reaction serves as a sinister catalyst for the development of gastric cancer.

Concurrent with these discoveries, the advent of adjuvant oncologic therapies has brought forth a beacon of hope for patients with advanced-stage gastric cancer. Surgery, once the mainstay of treatment, has gained a valuable ally in these therapies, which have demonstrated tangible benefits in prolonging life.

The pursuit of knowledge has also illuminated the underlying molecular pathogenesis of gastric adenocarcinoma, the most common subtype of gastric cancer. This newfound understanding has paved the way for significant advancements in managing two other malignant gastric neoplasms: gastrointestinal stromal tumors (GISTs) and marginal zone B-cell lymphomas (MALTs).

This comprehensive monograph serves as a testament to these remarkable advances, providing an up-to-the-minute overview of gastric cancer. It stands as an invaluable resource for gastroenterologists and other healthcare providers dedicated to the diagnosis, treatment, and management of this complex disease.

By delving into the pages that follow, readers will embark on a journey that encompasses the latest discoveries in gastric cancer pathogenesis, the emerging therapies that are transforming patient outcomes, and a detailed examination of the unique characteristics of GISTs and MALTs.