Gastrointestinal Pathology: Classification, Diagnosis, Emerging Entities, An Issue of Surgical Pathology Clinics, 1e (The Clinics: Surgery)

Understanding the Complexities of Gastrointestinal Pathology

The gastrointestinal tract, a complex and vital system, is susceptible to a myriad of inflammatory and neoplastic disorders. These conditions pose significant diagnostic challenges for surgical pathologists, necessitating continuous advancements in their understanding.

In this comprehensive issue of Surgical Pathology Clinics, we delve into a wide spectrum of gastrointestinal neoplasms, along with cutting-edge ancillary techniques that revolutionize diagnostic pathology. We also explore prognostic and predictive markers that have become indispensable in gastrointestinal pathology practice.

Our expert reviews provide crucial practical updates on some of the most challenging areas in this field, with a focus on differential diagnosis and potential diagnostic pitfalls. Key topics include:

Lymphomas of the Gastrointestinal Tract

Lymphomas, a diverse group of malignancies, can manifest in the gastrointestinal tract. Understanding their histopathological subtypes, clinical presentations, and therapeutic approaches is essential for accurate diagnosis and management.

Mesenchymal Tumors of the Gastrointestinal Tract Excluding GIST

Mesenchymal tumors, excluding gastrointestinal stromal tumors (GIST), are a heterogeneous group of lesions that may arise in the gastrointestinal tract. Proper classification and differential diagnosis are crucial for optimal patient outcomes.

Barrett’s Esophagus: Evolving Concepts in Diagnosis and Neoplastic Progression

Barrett’s esophagus, a precursor to esophageal adenocarcinoma, requires careful diagnosis and monitoring. This review explores the latest advancements in detection, surveillance, and management strategies.

Immunohistochemistry in Neoplastic Gastrointestinal Pathology

Immunohistochemistry plays a pivotal role in gastrointestinal pathology, aiding in the identification of specific proteins and their expression patterns. This technique enhances diagnostic accuracy and prognostication.

HER2 Testing in Adenocarcinomas of the Upper Gastrointestinal Tract

HER2 testing has become a standard in the management of upper gastrointestinal adenocarcinomas. This review provides an in-depth understanding of its significance and implications for patient care.

Pediatric Inflammatory Gastrointestinal Pathology

Inflammatory gastrointestinal diseases in children present unique diagnostic challenges. This article covers the histopathological features, clinical presentations, and management strategies of these conditions.

IgG4-Related Disorders of the Gastrointestinal Tract

IgG4-related disorders are a group of autoimmune diseases that can affect the gastrointestinal tract. Their identification requires careful pathological examination and integration with clinical findings.

This second volume in our series on gastrointestinal pathology builds upon the success of its predecessor, offering a comprehensive and practical resource for surgical pathologists. Under the expert guidance of Jason Hornick, Brigham and Women’s, this issue provides critical updates on the rapidly evolving field of gastrointestinal pathology.