Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery (Original PDF from Publisher)

The Interplay of the Microbiome, Metabolome, and Vagus Nerve in Disease and Recovery

Emerging Hypothesis of a Dysfunctional Circuit

The pioneering work of Elena L. Paley has shed light on a groundbreaking hypothesis: the existence of a dysfunctional circuit connecting the microbiome, metabolome, vagus nerve, and brain. This circuit is believed to play a pivotal role in a wide range of diseases and medical conditions, including:

• Alzheimer’s disease
• Dementia
• Aging-related cognitive decline
• Autoimmune conditions
• Inflammatory skin condition rosacea

Mounting evidence suggests that disruptions within this circuit can increase the risk of developing these and other health issues.

Associated Conditions Linked to Vagus Nerve Dysfunction

The vagus nerve, a crucial component of this circuit, is responsible for transmitting signals between the brain, gut, and various organs throughout the body. Its involvement in the dysfunctional circuit is associated with a number of conditions, including:

• Arnold’s reflex (abnormal coughing triggered by stimulation of the ear)
• Laryngopharyngeal reflux (LPR)
• Duodenogastric reflux (DGR)
• Gastroesophageal reflux disease (GERD)
• Pulmonary diseases

The Enigma of Human Health: Genome vs. Microbiome

At the core of this discussion lies a fundamental question: which holds greater significance for human health and intellectual abilities – the human genome or the human microbiome? Traditionally, the genome has been considered the primary determinant of our biological makeup. However, recent research has revealed the profound influence of the microbiome, a vast community of microorganisms residing within our bodies.

The Food-Gut Microbiome-Tryptamine-Vagus Nerve Circuit

Paley’s conceptual model proposes a novel mechanism for communication between the gut microbiome and the brain. This circuit involves the production of tryptamine, a neurotransmitter, by gut microbial fermentation. Tryptamine is then transmitted to the brain via the vagus nerve, triggering a series of physiological and cognitive responses.

This discovery deepens our understanding of the complex interplay between our gut health and overall well-being. It opens up new avenues for research and the development of innovative therapies that harness the power of the microbiome to combat disease and promote recovery.