Modern Concepts of Focal Epileptic Networks (Original PDF from Publisher)

Unveiling the Complex Landscape of Focal Epileptic Networks

In this comprehensive volume of the renowned International Review of Neurobiology, editors Elsevier Science delve into the intricate world of focal epileptic networks. Their meticulous examination illuminates the latest advancements in understanding the pathophysiology of epilepsy, focusing on the mechanisms underlying the formation and maintenance of these enigmatic brain circuits.

Seizures: From Initiation to Cessation

The authors delve into the intricate mechanisms governing seizure initiation, progression, and termination. They explore the role of neuronal excitability, ion channel dysfunction, and neurotransmitter imbalances in this complex interplay. By unraveling the intricacies of seizure dynamics, researchers can pave the way for more targeted and effective therapeutic interventions.

Limbic Networks: A Gateway to Seizures

Limbic structures, known for their critical role in emotional processing and memory formation, are often implicated in the development of focal epilepsy. This volume delves into the intricate interplay between limbic circuits and epileptic seizures, shedding light on the unique mechanisms that underlie their susceptibility to seizure generation.

Altered Metabolism: A Fuel for Epilepsy

The metabolic landscape of the brain plays a pivotal role in neuronal function and susceptibility to seizures. This volume examines the alterations in cerebral metabolism associated with the formation and progression of focal epileptic networks. By deciphering these metabolic aberrations, researchers can identify potential targets for novel therapeutic strategies.

Neocortical Focus and Malformation: The Roots of Epilepsy

Neocortical abnormalities, such as malformations of cortical development, are frequently associated with focal epilepsy. The authors investigate the pathological processes underlying these structural anomalies, exploring their impact on brain connectivity, excitability, and seizure susceptibility. Understanding the link between these developmental abnormalities and epilepsy holds promise for early detection and intervention.

Neural Network Dynamics: A Symphony of Seizures

The complex interactions between neurons within epileptic networks are essential for understanding the propensity of the brain to generate seizures. This volume explores the altered neural network dynamics that underlie the generation and propagation of epileptic discharges. By unraveling these intricate patterns of communication, researchers can unravel the mechanisms that lead to seizure initiation and propagation.

A Tapestry of Experts, A Wealth of Insights

This special volume benefits from the contributions of an internationally renowned editorial board and expert authors. Their collective insights provide a comprehensive and authoritative overview of modern concepts of epileptic focus organization. This comprehensive collection of reviews synthesizes the latest research, shedding light on the multifaceted nature of focal epilepsy and paving the way for innovative therapeutic approaches.